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Background

“An overwhelming 64 percent of wounded troops are blast injury survivors - an estimated 80 percent of them are expected to have sustained a traumatic brain injury. Many will return home from war undiagnosed until it is too late, and in many cases suffer permanent brain damage as a result.”


Military doctors estimate that 10-20 percent of the soldiers sent to Iraq or Afghanistan suffer from TBI.  Symptoms vary and include minor headaches or dizziness, fatigue, irritability, mood swings, ‘brain-fog’, attention/concentration deficits, vision problems, brief motor and sensory systems deficits and epilepsy.  Often the symptoms take time to materialize and are non-specific indicators of an underlying physical brain injury with dysfunction.

The consequences of not having an instrument that can identify and assist in early treatment for our soldiers (and civilian population) are enormous.  In addition to the cost of current medical treatment methods, TBI symptoms and cognitive deficits can reduce an individual’s quality of life and ability to apply “coping” mechanisms and become more fully involved in rehabilitation programs mandated by our government. 

This is of wider importance since the major burden of brain dysfunction, be it TBI, Alzheimer’s disease, or stroke, falls on caregivers.  Depression is common amongst this group due to additional financial difficulties, loss of independence, loss of time to run a home, and companionship issues.  Few adequate community resources provide support.  (See “Preventing, Treating and Living with Traumatic Brain Injury” at BrainLine.org)

Importance to Military

Need for non-invasive cerebral pressure measurements and identifying ‘signature’ of brain injury is overwhelming, especially in combat conditions. Abnormal cerebral pressure is assessed in most TBI by clinical signs and symptoms, but approach is unreliable. Study is intended to identify cerebral pressure ‘signature’ that defines injury: combat medical teams need to understand as quickly as possible the underlying brain damage to minimize life-long injuries. Suitable for rapid deployment during critical hours immediately following injury. 

Accelerate Appropriate Treatments

CCFP analyzer non-invasively detects and accelerates implementation of well defined therapeutic measures for conditions such as:  raised intracranial pressure (intracranial hypertension) and multiple conditions that cause abnormal “signature” intracranial pressure (ICP) waves (See Attachment II—Clinical Aspects of Using CCFP Analyzer).  Since it is non-invasive, it has the potential to provide triage en-route to hospital which could accelerate head injury management or provide warning of life-threatening conditions.

Avoidance of Secondary Brain Injury

A brain injury may cause swelling, and consequently excessive pressure that can produce further internal injury.  High intracranial pressure is the most frequent cause of death and disability in brain-injured patients.  The cerebral auto-regulation controls the brain blood supply and pressure.  Impairment of regulation leads to secondary brain insults and this occurs even with mild head injuries and anesthetics. CCFP provides: Identification of possible under-reported occurrences of concussion. (Late-life cognitive impairment, including early-onset dementia, depression, disturbances of executive function and impulse control.)  Opportunity to investigate secondary brain injuries with anesthesia for non-neurological injuries such as limb fractures.

Enhance Quality of Life of Affected Individuals, Families and Caregivers

Enabling a TBI victim to “cope” provides significant and possible life-long relief to family members and caregivers, as well as reducing financial burdens for the family and the government.  The identification of the physical brain injury is important in all TBI cases. Provides an object means of detecting TBI in cases of PTSD or multiple traumatic injuries where differential diagnosis is especially challenging. Provides a diagnosis to allow well-established treatments to be prescribed in cases where correct diagnosis and effective treatment was not previously possible.

The MMS-10/11 TMD Cerebral and Cochlear

Pressure Analyser: A Selection of Recent Web Links

 

Neurological Physics Group, Department of Medical Physics and Bioengineering, Southampton University Hospitals NHS Trust, UK.

http://www.medphys.soton.ac.uk/randd/Clinical/neuro/non-in.htm           Research

http://www.medphys.soton.ac.uk/Services/Patient/Neuro/tmd.htm         Clinical:  Balance and Hearing

http://www.medphys.soton.ac.uk/Services/Patient/Neuro/non-in.htm    Clinical:  Non-invasive Intracranial  

                                                                                                Pressure Assessment

Scientific Web Pages

http://www.marchbanks.co.uk

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Intracranial and Inner Ear Physiology and Pathophysiology
Andrew Reid, Robert Marchbanks, Arne Ernst
ISBN: 1-86156-066-4, Publishers John Wiley &  Sons Ltd, June 1998.

http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1861560664,descCd-tableOfContents.html

Amazon:-

http://www.amazon.com/Intracranial-Inner-Ear-Physiology-Pathophysiology/dp/1861560664

 

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London Press Service: Sound Way To Measure Fluid In The Brain

http://www.londonpress.info/lps/article.asp?uniqueid=5847&category=science

Proceedings of the Physiological Society

‘Non-invasive assessment of intracranial arterial and respiratory pressure waves via the trans aural route in man’. Lin, Jean-Pierre ; Rosenthal, Eric ; Marchbanks, Robert ;

Kings College London (2005) J Physiol 565P C19

http://www.physoc.org/publications/proceedings/archive/article.asp?ID=J%20Physiol%20565PC19

 

BBC News

'Headphones' brain monitor hope

 http://news.bbc.co.uk/1/hi/health/4104573.stm

 

UK Department of Health, Chief Scientific Officer’s Bulletin

CSO Bulletin: Issue 3 - February 2005

‘Scientist’s non-surgical brain pressure test’

http://www.dh.gov.uk/en/Publicationsandstatistics/Bulletins/Chiefscientificofficerbulletin/Browsable/DH_4103085

 

 

Forum for Science Industry and Business: Innovations Report

Brain Wave Monitor Could Replace Lumbar Puncture’

Physiological Society, London UK

http://www.innovations-report.com/html/reports/medicine_health/report-37936.html

 

NASA Bioastronautics Flight Research Program (BFRP)

‘The Role of Intracranial Pressure in Space Adaptation Syndrome E148 – ICP’

https://issmp.jsc.nasa.gov/science/default.asp?e_id=14


 

 British Tinnitus Association (BTA) Conference and AGM, Cambridge 2003

http://www.tinnitus.org.uk/index.php?q=node/135

 

International Tinnitus Journal 2007:-  Applications of the Marchbanks transcranial-cerebral sonography technique in neurootology: preliminary report.  Lehrer JF, Ogunlusi A, Knutsen J.

http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&cmd=retrieve&dopt=AbstractPlus&list_uids=17691661